After about a year on the said youth-oriented comedy variety-show, she transferred to GMA Network, where she became part of Ober Da Bakod with Janno Gibbs and Anjo Yllana.

In 1994, she bagged her first major role in Kadenang Bulaklak, where she starred alongside Ana Roces, Vina Morales, and Donna Cruz.

(Thank God It's Sabado) and Growing Up with Onemig Bondoc, Ciara Sotto, Raven Villanueva, Michael Flores, Rica Peralejo and Red Sternberg.

In late 2001, de Leon started bagging mother roles, beginning with Sana ay Ikaw na Nga.

In 2010, she returned to GMA with Ang Babaeng Hinugot sa Aking Tadyang, starring Marian Rivera and Dingdong Dantes.

It was for her work in the said soap that she was given rave reviews, complemented with the fact that she was back to her sexy figure and can give other young actresses a run for their money.

De Leon entered into politics when she filed her candidacy for councilor in Pasig's 2nd district for the May 2022 polls under Aksyon Demokratiko.