The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation.

[5] During pregnancy, angiopoietins act complementary to the VEGF system and contribute to endothelial cell survival and the remodeling of vessels.

Few studies have examined the role of angiopoietins in human pregnancy complications like preeclampsia and intrauterine growth restriction (IUGR).

[12] In a mouse model of PM, Plasmodium infection of pregnant mice led to decreased angiopoietin-1, increased angiopoietin-2, and an elevated ratio of angiopoietin-2/angiopoietin-1 in the placenta.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.