Angiopoietin receptor

The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis).

The angiopoietins are protein growth factors that regulate angiogenesis, the formation of blood vessels.

[1] Ang1 and Ang4 function as agonistic or activating ligands for Tie2, whereas Ang2 and Ang3 behave as competitive antagonists.

It is somewhat controversial which of the Tie receptors mediate functional signals downstream of Ang stimulation.

But it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins.

ANGPT1, ANGPT2, and ANGPT4 activate TIE-2. Intracellular signal transduction can proceed via DOK-R (yellow arrow) or alternatively via Akt to eNOS (orange arrow).
ANGPT1, ANGPT2, and ANGPT4 activate TIE-2. Intracellular signal transduction can proceed via DOK-R (yellow arrow) or alternatively via Akt to eNOS (orange arrow).