[3] If magnification difference becomes excessive the effect can cause diplopia, suppression, disorientation, eyestrain, headache, and dizziness and balance disorders.

The optics of the eye including its refractive power and axial length also play a major role in retinal image size.

[citation needed] Retinal aniseikonia occur due to forward displacement, stretching or edema of retina.

[4] A way to demonstrate aniseikonia is to hold a near target (e.g., a pen or a finger) approximately 6 inches directly in front of one eye.

[citation needed] Optical aniseikonia due to anisometropia can be corrected by spectacles, contact lenses or refractive corneal surgeries.

The optical magnification properties of spectacle lenses can be adjusted by changing parameters like the base curve, vertex distance, and center thickness.

The difference in magnification can also be eliminated by a combination of contact lenses and glasses (creating a weak telescope system).

The optimum design solution will depend on different parameters like cost, cosmetic implications, and if the patient can tolerate wearing a contact lens.