Anisonemia is a clade of single-celled protists belonging to the phylum Euglenozoa, relatives of the Euglenophyceae algae.

Species of this lineage have two flagella arising from the anterior region of the cell, unlike their relatives, Peranemida and Euglenophyceae, where only one flagellum is emmergent.

[1] In particular, Anisonemia, Euglenophyceae and the phagotrophic Peranemida form a clade known as Spirocuta, distinguished by a greater number of pellicle strips than other euglenids.

He proposed it as a subclass of the obsolete class Peranemea, which is paraphyletic with respect to Euglenophyceae, containing Peranemida in addition to Anisonemia.

It contains two orders, differentiated by their modes of locomotion: Anisonemida, phagotrophs that perform a gliding motion with their anterior flagellum, and Natomonadida, which move by swimming.