She currently is a member of the German Bundestag representing Schweinfurt for the Christian Social Union in Bavaria (CSU), part of the European People's Party (EPP).

In her capacity as member of the committee on the Environment, Public Health and Food Safety, Weisgerber issued a report on the 2007 revision of the EU Directive on Air Quality.

On the committee on the Environment, Nature Conservation, Building and Nuclear Safety, she serves as her parliamentary group's spokeswoman and as rapporteur on urban development funding and on climate change.

[3] In the negotiations to form a coalition government under the leadership of Chancellor Angela Merkel following the 2017 federal elections, Weisgerber was part of the working group on urban development, led by Bernd Althusmann, Kurt Gribl and Natascha Kohnen.

In 2019, she was appointed by the leaders of CDU and CSU, Annegret Kramp-Karrenbauer and Markus Söder, to the parties’ ad hoc steering group on climate policy.