The station is on the rail corridor which connects east and west Turkey, which is high speed between Istanbul and Sivas.

The ATG building serves as a hub for high-speed rail with its own concourse containing information and tickets booths, waiting rooms and a VIP lounge, and is connected to the rest of the station via a skybridge.

During the Turkish Independence War, CFOA transported troops from Ankara, as the newly named capital of Turkey, to the front near Eskişehir.

The CFOA, now under Turkish control, finally opened the line to Kayseri and Ankara was no longer the terminus.

[2] In 1927 the Anatolian Express was inaugurated as a premier overnight train from Istanbul to Ankara operated by the Compagnie Internationale des Wagons-Lits (CIWL).

In 1972, the station, along with the track between Sincan and Kayaş, were electrified with 25 kV AC catenary for the Ankara Suburban Railway.

Two bombs were detonated outside the entrance of the Ankara Central railway station, killing more than 105 and injuring more than 400 people.