Brody started acting on stage when she was nine years old in a children's theatre in New York.

People that she worked with included Norma Talmadge, Wally Van, Hughie Mack, and Flora Finch.

[2] The San Francisco Examiner wrote in 1929 that Brody has one of her best roles in the film My Man.

[5] The Los Angeles Evening Post-Record in 1933 said, "Ann Brody, whose Jewish maternal characterizations are stage and screen classics, is returning to the footlights once more".

[7] She died in a New York City hotel room on July 16, 1944, from what appeared to be natural causes.