In October 2009, the Chicago Symphony Orchestra (CSO) named Clyne and Mason Bates its co-composers in residence, as of the 2010–2011 season,[5] with an initial contract of 3 years.
[7] Various arts institutions have commissioned and presented Clyne’s work, including the Barbican, Carnegie Hall, Kennedy Center, Los Angeles Philharmonic, MoMA, Philharmonie de Paris, Royal Concertgebouw Orchestra, San Francisco Ballet, and the Sydney Opera House.
[17][18] Clyne was nominated for the 2015 Grammy Award for Best Contemporary Classical Composition for her double violin concerto, Prince of Clouds.
Works for soloist and orchestra form an important part of her output, as is also evident from The Seamstress (2015), a single-movement violin concerto that incorporates a whispered recitation of the poem A Coat by Yeats,[18] and the five movement cello concerto Dance (2019), commissioned by Inbal Segev and recorded by her in 2020.
Clyne has done several cross-genre collaborations, and has also worked with Yo-Yo Ma, Pekka Kuusisto, Martin Fröst, and Jess Gillam.