Based on the classic 1877 Leo Tolstoy novel of the same name, it focuses on the tragic title character, a fashionable but unhappily married woman, and her ill-fated liaison with Count Vronsky, which ultimately leads to her downfall.

Anna falls in love with the handsome and charming Count Alexei Vronsky, but she is torn by her loyalty to her husband and small son.

Meanwhile, Vronsky had first courted Ekaterina "Kitty" Alexandrovna Shcherbatsky, who chose him over gentleman farmer Konstantin Dmitrievich Levin.

Anna's choice of love over duty leads to tragedy: Her affair with Vronsky is revealed, and she is shunned; eventually, she throws herself in front of an oncoming train.

A recording of the musical released on August 7, 2007, stars Melissa Errico as Anna, Gregg Edelman as Levin, Brian d'Arcy James as Vronsky, Jeff McCarthy as Karenin, Marc Kudisch as Oblonsky and Kerry Butler as Kitty.