Her father played hockey for HC Košice, while her mother was a Czechoslovak national champion in water skiing.

[3][4] Her younger sister, Kristína Schmiedlová, was also a tennis player, but ended her career at the age of 21 to study medicine.

[8] In May, Schmiedlová won the Empire Slovak Open in Trnava when she defeated defending champion Barbora Záhlavová-Strýcová in the final.

[12] In February, she reached her first WTA Tour final at the Rio Open, losing to Sara Errani in straight sets.

In April, she won her first WTA career title at the Katowice Open, where she defeated Camila Giorgi in the final.

[14] Schmiedlová won her first match of the season at the Sydney International beating sixth seed Timea Bacsinszky in the first round.

132 in the world, Schmiedlová won her third career title at the Copa Colsanitas in Bogotá, Colombia, where she beat Lara Arruabarrena in the final.

[20] Playing in the Fed Cup tie versus Great Britain, Schmiedlová helped Slovakia win 3–1 by beating Heather Watson and Harriet Dart.

[24] A week later, competing at a $25k tournament in Irapuato, Mexico she was defeated in the first round by eighth seed Renata Zarazúa.

[25] In the leadup to the French Open, Schmiedlová played the İstanbul Cup and made it to the second round before she was defeated by Aliaksandra Sasnovich.

100, she reached the fourth round of the French Open for the first time at a major event in her career, defeating 11th seed Veronika Kudermetova, lucky loser Aliona Bolsova, and qualifier Kayla Day.

Schmiedlová was the first Slovak to reach the second week at a major since Magdaléna Rybáriková at the 2018 Australian Open, and the first to do so at Roland Garros since Dominika Cibulková's 2012 quarterfinal run.

[44][45][46] However, she lost the bronze medal match to Iga Świątek in straight sets, despite breaking her serve at the start.