Marchesini graduated in Psychology at the Sapienza University of Rome in 1975 and attended, from the following year, the Silvio D'Amico National Academy of Dramatic Arts.
[3] In 1990, the Trio reaches the peak of success with the parody of Alessandro Manzoni's The Betrothed, which was broadcast on Rai 1 in 5 episodes.
The Trio dissolved in 1994, due to the will of all three actors to work as soloists,[5] but reunited for one last time in 2008 to celebrate its 25th anniversary with the TV program Non esiste più la mezza stagione.
[2] As a soloist, Marchesini took part to several TV programs, giving impressions of many famous characters, such as Gina Lollobrigida and Rita Levi-Montalcini.
Since 2000, Marchesini began as well her writing career with several collections of stories and short comic monologues, like ...che siccome che sono cecata (...since I am blind, 2000), quoting one of her most famous catchphrases,[6] Il terrazzino dei gerani timidi (The terrace of shy geraniums, 2011)[7] and Moscerine (Gnats, 2013).