In 1973, Anna Maria College became coeducational, and a year later, began graduate degree programs.

[4] On April 3, 1980, the Sisters of Saint Anne ceased involvement in running the school, and a Board of Trustees was established.

In 2004, the college established the Molly Bish Center for the Protection of Children and the Elderly.

[7] Anna Maria College has thirteen Division III athletic teams, known as the AMCATS (Anna Maria College Athletic Team Sports), in the National Collegiate Athletic Association (NCAA), including men's baseball, basketball, cross country, football, ice hockey, lacrosse, and soccer; and women's basketball, cross country, field hockey, soccer, softball, tennis, and volleyball.

Anna Maria was also a charter member of the Commonwealth Coast Conference (CCC), which it competed in from 1984 to 2011 before joining the GNAC.