She was born in Gumpoldskirchen in Lower Austria in 1850, where her father Franz Hofmeister was a schoolteacher and director of the choir of St Michael's Church in the town.
She had early lessons in singing and violin from her father, then from 1864 to 1866 attended Vienna Conservatory, studying violin from Georg Hellmesberger Sr. and singing from Adele Passy-Cornet; she afterwards trained further with Heinrich Proch, conductor of the Vienna Court Opera.
[1][2][3] Her debut was as Leonora in Verdi's Il trovatore in Olmutz (present-day Olomouc) in 1871.
[1][2][3] Sachse-Hofmeister's repertoire included operas of Mozart, and leading roles in Beethoven's Fidelio, Weber's Euryanthe and Verdi's Aida.
She appeared in London in Wagner's opera cycle Der Ring des Nibelungen in 1884.