[1][2] She was the second legitimate daughter of Galeazzo Maria Sforza, Duke of Milan, and his second wife, Bona of Savoy.
[2] Anna's paternal grandparents were Francesco I Sforza and Bianca Maria Visconti, and her maternal were Louis, Duke of Savoy and Anne de Lusignan of Cyprus, for whom she was named.
[3] When Anna was an infant, her father was assassinated inside the Church of Santo Stefano in Milan on 26 December 1476, which was the Feast Day of St.
Her wedding with Prince Alfonso d'Este took place fourteen years later, on 12 January 1491, amidst banquets, receptions, and theatrical representations.
[7][better source needed][8][9] The supposed unhappiness of the marriage, however, may also have been due to Alfonso's well-known reputation for extramarital affairs.