The station was the first established in the area when Patrick Drinan took up the run in July 1876.
The Collins brothers then sold Annandale to Edward Wienholt in 1881; Wienholt was a well-known pastoralist and held properties such as Katandra, Warenda and Saltern Creek.
[3] In 1911 the area was hit by a drought, with Annandale receiving only 0.18 inches (5 mm) of rain in the first seven months of the year.
[4] Between 1914 and 1916 the area was again struck by drought; about 10,000 cattle died on the station during this time.
Kidman lost over 75,000 head of stock on all of his properties through the channel country including Diamantina Lakes, Durham Downs, Innamincka and Sandringham Stations.