She is the author of The Romance of Happy Workers (2008),[1] The 2000s (2009),[2] My Common Heart (2011),[3] Garments Against Women (2015),[4] The Handbook of Disappointed Fate (2018),[5] and The Undying: Pain, Vulnerability, Mortality, Medicine, Art, Time, Dreams, Data, Exhaustion, Cancer, and Care (2019).

[6] In 2016, she was a featured blogger at the Poetry Foundation, where she wrote an ongoing series of posts about her diagnosis and treatment for a highly aggressive form of breast cancer, as well as the lives and near deaths of poets.

With Guillermo Parra and Cassandra Gillig, she has translated the work of 20th century Venezuelan poets Victor Valera Mora, Miguel James, and Miyo Vestrini.

In 2020, Boyer was awarded the Pulitzer Prize for General Nonfiction for her book The Undying: Pain, Vulnerability, Mortality, Medicine, Art, Time, Dreams, Data, Exhaustion, Cancer, and Care.

Boyer attempts to abandon literature in the same moments that she forms it, turning to sources as diverse as Jean-Jacques Rousseau, the acts of sewing and garment production, and a book on happiness that she finds in a thrift store.

"[23] The Undying: Pain, Vulnerability, Mortality, Medicine, Art, Time, Dreams, Data, Exhaustion, Cancer, and Care tied for winner of the 2020 Pulitzer Prize for General Nonfiction.