The Anne C. and Frank B. Semple House is a historic house in the Stevens Square/Loring Heights neighborhood of Minneapolis, Minnesota, United States.

[2] The house was listed on the National Register of Historic Places in 1998.

The entry on Franklin Avenue has a balustraded entry porch with Ionic columns, a detailed Palladian window, and a rounded bay.

The interior has a reception hall with mahogany paneling, a hardwood floor with marble inlays, and a frescoed ceiling.

Interior spaces include a 1,000-square-foot (93 m2) living room and a ballroom.