In 1956, she was nominated for the Tony Award for Best Featured Actress in a Play for her performance in Paddy Chayefsky's Middle of the Night.

[7] Jackson's mother was of Irish Catholic descent and her father, whose original name was Ivan Jakšeković, had emigrated from Croatia (then part of Austria-Hungary) in 1918.

Her theater credits included Summer and Smoke, Arms and the Man, Luv, The Waltz of the Toreadors, Mr. Peters' Connections and Lost in Yonkers.

Her many television appearances include Armstrong Circle Theatre, Academy Theatre, The Philco Television Playhouse, Studio One, The Untouchables, The Defenders, multiple appearances, as different, similar, characters on Gunsmoke, Marcus Welby, M.D., Rhoda, The Facts of Life, Highway to Heaven, Law & Order, and ER.

[citation needed] In March 2017, the Harry Ransom Center announced the acquisition of Anne Jackson's archive along with her husband's.