In the 2000s and 2010s, Lockhart had several recurring and multiepisode minor roles on series such as The Lying Game, Dragnet, The West Wing, NCIS, the Law & Order franchise shows, and Chicago Fire.
That same year, she appeared in the critically acclaimed Hallmark Hall of Fame episode Lisa, Bright and Dark, alongside Kay Lenz, Anne Baxter, and John Forsythe.
Her other film credits include Just Tell Me You Love Me (1978), Hambone and Hillie (1983) opposite Lillian Gish,[5][6][7] Young Warriors (1983), The Oasis (1984), The Serpent Warriors (1985), Dark Tower (1989), Big Bad John (1990), Bug Buster (1998), A Dog's Tale (1999), Daybreak (2000), Cahoots (2001), Hollywood, It's a Dog's Life (2004), ExTerminators (2009), and Dakota's Summer (2014).
Though Lockhart herself claims no recollection of being approached,[8] she was reportedly John Carpenter's first choice to play the role of main character Laurie Strode in Halloween (1978).
In recent years she has appeared onstage as Eleanor in The Lion in Winter (2010) and as Virginia in It's Only a Play (2016) at River City Repertory Theatre.
[11] A Catholic, Lockhart met Pope John Paul II in 1985 when she was invited to attend a papal audience in St. Peter's Square.