She was a daughter of Thomas Wentworth, 1st Earl of Cleveland (1591–1667) and the former Anne Crofts (died 1638).
Their father was a prominent English landowner and Royalist general during the Wars of the Three Kingdoms.
After her mother's death in 1638, her father married Lucy Wentworth (a daughter of Sir John Wentworth, 1st Baronet, of Gosfield), with whom he had another daughter, Catherine (who married William Spencer, brother of Nicholas Spencer).
[1] Her paternal grandparents were the former Anne Hopton (a daughter of Sir Owen Hopton) and Henry Wentworth, 3rd Baron Wentworth, who owned an estate near Nettlestead, Suffolk and was one of the judges of Mary, Queen of Scots at Fotheringay in 1586.
Together, they lived at Ladye Place at Hurley which her husband inherited on the death of his father.