[1] Anne Marie served as regent for the first time during the trip of Victor Amadeus in 1686, and was said to have handled the task well despite her young age.

[1] When Victor Amadeus severed his ties with France in 1690, Anne Marie and her children accompanied her mother-in-law when they left the capital in protest.

[6] Despite his marriage ties to France, Victor Amadeus joined the anti-French side in the War of the Spanish Succession.

Anne Marie was appointed by him to serve as regent of Savoy during his absence in the war, a task she handled with maturity and judgment.

[7] When the war was ended in 1713 by the Treaty of Utrecht, Victor Amadeus received the Kingdom of Sicily, formerly a Spanish possession.

Anne Marie's stepmother wrote: I shall neither gain nor lose by the peace, but one thing I shall enjoy is to see our Duchess of Savoy become a queen, because I love her as though she were my own child ...[8] When Victor Amadeus left for his coronation in Sicily, he had originally planned to leave Anne Marie behind to function as regent in his absence, but as he feared that she would let herself be directed by his mother because of her loyalty to her, he changed his mind and took her along with him instead.

At the death of her eldest son in 1715, both she and Victor Amadeus fell into severe depression and left the capital to mourn, leaving Marie Jeanne to handle their official duties.

She was displaced as heir by the birth of the Old Pretender's son, Charles Edward Stuart ("Bonnie Prince Charlie"), on 31 December 1720.

Charles Edward and his brother Henry, Cardinal Stuart, both died without legitimate issue, so the descendants of Anne Marie d'Orléans inherited the Jacobite claim, i.e. they would have inherited the British crown had it not been for the Act of Settlement, which excluded the claims of the Catholic Stuarts and d'Orléans and settled the throne on the nearest Protestant relatives, the Hanoverians.