[4] The campaign unseated longtime Democrat Jim Oberstar and gave the 8th district of Minnesota its first Republican representative in 78 years.

[6][7] She worked as the executive director of the Minnesota House Republican Campaign Committee, and helped recruit women candidates to run for legislative office.

Neu Brindley first ran after the Minnesota Supreme Court ruled that three-term Republican incumbent Bob Barrett was ineligible to run because he did not meet residency requirements, triggering a special election.

[23] Neu Brindley successfully proposed an amendment to a bill banning conversion therapy in the state to exclude clergy working with members of their congregation.

[26][27] Neu Brindley opposed legislation to allow medically assisted suicide in the state, sharing the story of her husband, who died of ALS.

[32][33] In 2021, Neu Brindley served on a working group to distribute $250 million in federal aid to front-line workers during the COVID-19 pandemic.

[42] She signed a letter opposing the Mayo Clinic's vaccine mandate policy for employees, calling it "onerous" to receive a religious exception.

"[44] In 2018, Neu Brindley authored legislation to ban people convicted of a DWI from operating a snowmobile or all-terrain vehicle after an accident killed a child on Chisago Lake.

[47][48][49] She said she was worried about proposals that would increase training, discipline, and civilian oversight for police officers and advocated for delaying implementation of a new standard for justified use of deadly force.

[50][51] She attempted to amend a larger public safety bill to ban cities from disbanding, abolishing, or defunding police departments, and supported requiring reports on the use of mandatory minimum sentences in the state.