Anne Spencer, Countess of Sunderland (née Digby; c. 1646 – 26 April 1715) was the wife of Robert Spencer, 2nd Earl of Sunderland and the daughter of George Digby, 2nd Earl of Bristol and Lady Anne Russell.
The groom had previously broken off their long-standing engagement; according to Samuel Pepys he told his friends that he had reason enough and was resolved never to have her.
She was a lady-in-waiting to Mary of Modena during the reign of James II, and was present at the birth of the Prince of Wales, signalling to the king that his new child was a boy.
She became a close friend of Sarah Churchill, later Duchess of Marlborough, and was disliked by Queen Anne, who was jealous of their friendship.
Her devotion to her husband was never seriously questioned; his biographer considered that it was principally his happy marriage which sustained Sunderland through a long and unhappy life.