She was first the wife of Sir Walter Herbert and then George Hastings, 1st Earl of Huntingdon, and served in the household of King Henry VIII's daughter, the future Queen Mary I.

[3] In 1483, Richard III executed her father for treason, following his part in the uprisings which became known as Buckingham's rebellion.

[citation needed] After Herbert died in 1507, Anne gave control of her jointure, which included Raglan Castle in Wales, to her brother, Edward.

However, in 1523 Compton took the unusual step of bequeathing land to Anne in his will, and directing his executors to include her in the prayers for his kin for which he had made provision in his will.

They had five sons and three daughters:[9] In the second season of the Starz TV show The Spanish Princess she is played by actress Tessa Bonham Jones.