In 2004, after meeting director Schorsch Kamerun at the Zurich Schauspielhaus, she collaborated with him on a theatrical adaptation of The Snow Queen, based on Hans Christian Andersen's fairy tale.

Blendl took roles in feature films such as Michael Klier's Farland (2004), Christian Petzold's Ghosts (2005), and Stephan Geene's After Effect (2007).

In addition, she played lead roles in the directorial debut and graduation films Maria am Wasser by Thomas Wendrich (2006) and Transit by Philipp Leinemann (2010).

Since October 2019, Blendl has starred as Detective Pia Walther, grieving the loss of her husband under the leadership of Maike Riems (Anja Kling) in the ZDF crime series Das Quartett.

Blendl's graduation project at the HFFM, the feature film with documentary elements All I never wanted, co-directed with Leonie Stade, was also produced by her company.