António Manoel de Vilhena (28 May 1663 – 10 December 1736) was a Portuguese nobleman who was the 66th Prince and Grand Master of the Order of St. John of Jerusalem from 19 June 1722 to his death in 1736.

Vilhena was also a remote descendant by one of his direct paternal branches of the noble and royal Castilian House of Manuel de Villena [es].

[3] The renovation was entrusted to the French architect Charles François de Mondion, who designed a number of Baroque buildings in the largely medieval city.

A bronze statue of the Grand Master was installed in the fort's piazza in 1736, and it was relocated a number of times before being placed in its present location at Pope John XXIII Square in Floriana.

[5] Apart from the construction of Fort Manoel and the restoration of Mdina's walls, a number of improvements were made to the fortifications of Malta throughout Vilhena's magistracy.

Saint Anthony's Battery was built on Gozo, the fortifications of Birgu were strengthened, and work continued on the unfinished Cottonera Lines.

[2] In 1724, the Grand Master founded a suburb called Borgo Vilhena in order to meet the demand for housing within the capital Valletta.

[13] Vilhena's magistracy was marked by the only attempt to end the perpetual war between the Order and the Ottoman Empire and establish a peace treaty.