The place is mentioned more frequently from the 18th century when the Antanavas Manor belonging to a statesman of the Grand Duchy of Lithuania Jonas Antanas Chrapovickis [lt] (Jan Antoni Chrapowicki) was founded.

At the end of the 18th century, on the initiative of the Chrapovnicki family, a spirits distillery was established, and a hexagonal chapel with two sacristies and deep cellars was built with hewn timbers.

It was intended to become the family mausoleum, but it did not fulfill this purpose lords themselves used to attend prayers at the Pilviškiai church, and the chapel was "given" to the local peasants.

In addition to beer and vodka, distillery also produced Antanavas liqueur, which was sold in Vilnius, Warsaw and other larger cities.

The distillery employed seven craftsmen ( blacksmiths, barrel makers, boiler operators and others) on a permanent basis, with up to 30 additional employees.

During World War I, in April 1915, the Imperial Russian Army fought against German troops in the Gaisriai [lt] – Antanavas Manor area but was forced to retreat.

In 1944, the manor buildings and the distillery were used as a base for a unit of the French Fighter Squadron 2/30 Normandie-Niemen, which made flights to East Prussia.

The chapel was given to the Antanavas distillery, and the paintings and liturgical items were taken to the Atheism Museum in Vilnius, which was established by the occupying Soviet Union in the Church of St. Casimir.

On 9 July 2011, on the celebration of the 250th anniversary of Antanavas, the Bishop of Vilkaviškis, Rimantas Norvila, consecrated the newly restored chapel and conferred on it the title of the Blessed Virgin Mary, the Patroness of Families.