He scored 37 points and grabbed 20 rebounds in Cibona's 89–85 win over MZT Skopje Aerodrom, in a game that was decided after double overtime.

[4] With Darüşşafaka, Žižić made his debut in the European top-tier level, the EuroLeague, on 30 December 2016, in an 81–77 road loss against FC Barcelona.

[7] Before even suiting up for a single regular-season game for the Celtics, Žižić was traded to the Cleveland Cavaliers alongside Isaiah Thomas, Jae Crowder, and the Brooklyn Nets' unprotected 2018 first-round pick for Kyrie Irving on 22 August 2017.

[8] However, eight days after the trade was first confirmed, the Celtics would also add a 2020 second-round pick from the Miami Heat in order to fully complete the deal to satisfy Cleveland's worries involving Thomas's hip injury.

On 11 March, he scored 15 points and recorded 7 rebounds (both career highs) in a loss to Los Angeles Lakers.

On 25 August 2020, Žižić signed a two-year deal with Israeli team Maccabi Tel Aviv.

[15] On 22 June 2022, Žižić signed a three-year (2+1) contract with Turkish club Anadolu Efes, the reigning back-to-back EuroLeague champions.