Rebić began his senior career at RNK Split, and in 2013 signed for Serie A club Fiorentina for an undisclosed fee.

He spent most of his time there out on loan to RB Leipzig, Hellas Verona, and Eintracht Frankfurt, before joining the latter permanently in July 2018.

[2] Rebić made his debut for the first team against Dinamo Zagreb on 21 May 2011 in the last round of the 2010–11 Prva HNL as a second-half substitute.

[7] He made a debut on 30 September, coming on as a 36th-minute substitute for injured teammate Giuseppe Rossi, in a 2–2 home draw against Parma.

[11] After his loan spell with Leipzig ended, Rebić returned to Fiorentina and was given the number 11 shirt, previously worn by Juan Cuadrado, and was used primarily on the left wing.

On 20 March, on as a halftime substitute for Giampaolo Pazzini, he was sent off for two yellow cards at the end of a 2–1 loss to Carpi in the Stadio Marc'Antonio Bentegodi.

[13] Rebić joined Bundesliga club Eintracht Frankfurt on a season-long loan on 11 July 2016, reuniting with former national team manager Niko Kovač.

[14] After a short battle with mononucleosis, Rebić made his debut on 17 September against Bayer Leverkusen, coming on as a substitute and assisting Marco Fabián for the winning goal in a 2–1 victory.

[19] This included two goals on 19 May in the 2018 DFB-Pokal Final, a 3–1 victory that gave his club their first cup since 1988 and denied Bayern Munich to complete their double.

[24] On 2 September 2019, Rebić returned to Italy and signed a two-year loan deal with Serie A club AC Milan, with André Silva moving in the other direction.

After spending the first half of the season on the bench, having played more minutes for the national team than the club,[25] Rebić scored his first two league goals in a 3–2 victory over Udinese on 19 January 2020, having come on as a half-time substitute for Giacomo Bonaventura.

[38] On 27 September, he won a penalty that Franck Kessié successfully converted into the first goal of the 2–0 victory over Crotone; however, in the 58th minute of the game, he fell during a counterattack and dislocated his elbow.

[44] On 9 May, he scored a spectacular goal in a 3–0 victory over Juventus, winning Milan crucial three points for the Champions League qualification.

[66] In the second group match against Argentina in Nizhny Novgorod, he volleyed after a mistake by opposing goalkeeper Willy Caballero to open a 3–0 Croatian win.

[67] In the Round of 16 match against Denmark, he had a chance to score near the end of extra time but was fouled by Mathias Jørgensen; Luka Modrić missed the resulting penalty but the Croats won in the shootout.

[70] After he had been benched at the club, his drop in form could also be seen in the qualifying games, which caused a public outcry and endangered his spot in the Euro squad.

[71][72][73][74] After missing the majority of Croatia's 2020–21 Nations League campaign due to injuries,[75] Rebić was included in Dalić's final squad for the UEFA Euro 2020.

[85][86] Ahead of the September World Cup qualifiers against Russia, Slovakia and Slovenia, Rebić was omitted from the national team.

[90] His first touch, however, has been cited as one of the areas of his game that is in need of improvement, with the others being the accuracy of his passing, crossing, and shots from long range, as well as his decision-making in high-pressure situations.

[92][93] Aside from his attacking duties, he has been praised for his willingness to participate in his team's defensive plays, including the pressing or counter-pressing of the opposition.