The three times per day AVE service between Madrid Atocha and Granada covers the distance of 568 km (353 mi) in 3 h 5 min.

The daily AVE train between Granada and Barcelona Sants connects the two cities in 6 h 25 min.

[4] After branching from the existing Antequera-Santa Ana railway station, the line serves Loja and Granada.

In 2019, construction was set to begin on a €16 million underground AVE station in Antequera town centre, making Antequera the only city in Spain outside of Madrid to have two high-speed rail stops.

[6] Since December 2024 a daily Alvia service Madrid-Almeria via Granada on S-730 trains is using the line [7] In addition medium distance high speed Avant services connect Granada to Málaga and to Seville on trains calling at Loja and Antequera-Santa Ana.