[2][3] A variety of structures lie close to the anterior superior iliac spine, including the subcostal nerve,[5] the femoral artery (which passes between it and the pubic symphysis),[4] and the iliohypogastric nerve.

[6] The anterior superior iliac spine provides a clue in identifying some other clinical landmarks, including McBurney's point, Roser-Nélaton line, and true leg length.

It is an important surface landmark for various surgical approaches, such as treatment of hernia.

[5] As the subcostal nerve lies close to the anterior superior iliac spine, this is put at risk of damage.

[8] It is considered to be a "discreet" location for concealing cosmetic surgery scars and ports.