[10] The anterior sides of the tarsal segments of each leg of female A. manicatum have fine, soft and small white-colored hairs.

It has also recently been documented in the Canary Islands, and South American countries such as Argentina, Brazil, Paraguay, and Uruguay.

[17] This species' tendency to occupy ready-made nesting sites, usually movable objects, allows it to spread to new locations easily.

[11] In Europe, this species is normally found in gardens, fields, and meadows in the southern part of Wales and England, but is localized in other places within the United Kingdom,[4] where they can be seen from May to September.

[18] Being a member of the Anthidiini tribe of megachilid bees, A. manicatum engages in highly elaborate nesting behavior.

These bees construct their nests in pre-existing cavities, using the trichomes of wooly plants such as lamb's ears (Stachys byzantina).

Inside the cavity, the bees fashion the trichome ball into cells, where they deposit an egg and a provisioning mass consisting of nectar and pollen.

Once finished, she seals the entrance to the cavity with a terminal plug, which consists of inorganic and organic materials that she brings to the nest.

[19] Besides trichomes, other materials used by a female A. manicatum for building brood cells include mud, stones, resin, and leaves.

Additionally, females use specialized hair-like structures on the exterior of their tarsi to absorb the secretions of the plant hairs to apply onto the brood cells.

A. manicatum displays extreme polyandry, which is linked to male territoriality and resource defence of flowering plants.

However, males of the genus Anthidiellum chase away intruders rather than physically attacking them, so their aggressive behaviour differs significantly.

[22] Resource defence, as exhibited by male A. manicatum bees, has been thought to benefit females by reducing foraging competition for pollen and nectar.

[19] The territorial behaviour of males develops after a period of flight without any localisation in search of a suitable flower patch.

[26] This is due to the females' polyandrous behaviour, and can also be attributed to a phenomenon called "late male sperm precedence".

Although females do have a spermatheca for long-term sperm storage, more recent mates tend to father the brood she produces.

Studies have shown that A. manicatum males that copulate late in a sequence have a greater than average chance of paternity of the female's eggs.

[1] Both males and females can maintain a precise static hover near flowers similar to flies in the family Syrphidae.

[27] Unlike most other species of Hymenoptera, male A. manicatum bees are larger than females in size, displaying male-biased sexual dimorphism.

The selection for larger size in males may have resulted due to their aggressive territorial behavior and subsequent differential mating success.