Anthocleista nobilis has been recorded from Angola, Central African Republic, Republic of the Congo, Côte d'Ivoire, Equatorial Guinea, Ghana, Guinea, Liberia, Nigeria, Mali, Sao Tome and Principe, Senegal, and Sierra Leone.

[1][3] Anthocleista nobilis is a medium-large tree that can grow between 4 and 30 meters tall.

It typically grows in secondary jungles, roadsides and disturbed sites.

[4] Anthocleista nobilis root bark is used by the Mbano people of Nigeria for treatment of Diabetes mellitus, Malaria, gastrointestinal worms and jaundice.

[5] In 2018, a study found that Anthocleista nobilis could be a potential source for anti-inflammatory and analgesic lead compounds.