Del Col was born and raised in Timmins, Ontario, Canada[4] and is a graduate of Wilfrid Laurier University,[5] the Canadian Film Centre[6] and the Sundance Institute's New Frontier Story Lab,[7] Del Col has produced feature films in Canada, including serving as executive producer on the Nelly Furtado Loose Live album CD.

[10] Along with Conor McCreery, Del Col is the co-creator and co-writer of Kill Shakespeare, which debuted in comic book format in April 2010.

[2] Kill Shakespeare is described by the New York Times as, "gripping, violent and dark fun, even if you're not fully versed in Shakespearean lore".

Del Col has been a lifelong fan of the characters and was successful in working with Simon & Schuster to secure the comic book rights and then pitch to publishers.

The series was the first to star a female modern-day lead character, Charlotte de la Cruz and garnered a great amount of positive reviews.

Leading comics site TheMarySue.com said, "It's a fantastic video game based title; it really captures a lot of spirit of Assassin's Creed…captures your imagination from the get-go.

In 2018, Del Col co-created the Image original graphic novel Son of Hitler with writer Geoff Moore and artist Jeff Mccomsey.

[30] Matt O'Keefe of ComicsBeat called it a "page-turning graphic novel", offering "an alternate history story with obvious respect for the actual events of World War 2".

[32] Son of Hitler brings together many aspects of Del Col's comics work in one volume; it shares the historical elements of Del Col's Kill Shakespeare and Assassin's Creed comics and the classic mysterious noir elements of his Nancy Drew & The Hardy Boys.

[33] Everyman was called an interesting unconventional look at the Marvel universe, with critics highlighting Del Col's humanizing portrayal of Luke Cage and Lindsay's realistic depiction of Harlem.

[34] On May 8, 2022, Del Col — along with collaborators Fahmida Azim, Josh Adams, and Walter Hickey — were the recipients of the first-ever Pulitzer Prize for Illustrated Reporting and Commentary for their work on "I Escaped a Chinese Internment Camp," published by Insider.