On 6 July 2023 it was announced that Joshua would rematch Dillian Whyte on 12 August at The O2 Arena in London, England on DAZN PPV.

On 5 August, it was announced that Whyte returned a positive drug test conducted by the voluntary anti-doping agency.

[7] A number of individuals such as Gerald Washington and Derek Chisora were considered to replace Whyte.

[10] After boxing relativity tentatively for the first six round, Joshua scored a one punch knockout in the 7th, with a double feint followed by a right sending the Finn to the canvas, with referee Victor Loughlin stopping the bout without completing a count.

He tested positive for clomifene, although the boxer denied intentional doping and blamed the consumption of contaminated egg and chicken.