[6][7] On 6 December he first appeared in the UEFA Europa League, in a 2–0 home win over Hapoel Ironi Kiryat Shmona that allowed the team to advance unbeaten into the knockout stages.

[8] Lopes' maiden appearance in Ligue 1 took place on 28 April 2013, in a 1–1 home draw against Saint-Étienne in the Derby du Rhône where he made an early close-range save from Pierre-Emerick Aubameyang, later conceding the first goal from a Kurt Zouma header.

[11][12] He featured in their run to the domestic League Cup final, where they lost 2–1 to Paris Saint-Germain in the decisive match at the Stade de France on 19 April 2014.

[13] On 3 December 2016, during a league game, Lopes was hit by a firecracker thrown from the stands as he was laying injured in the penalty area at the Stade Saint-Symphorien, home to Metz.

[23] After maintaining the starting role in the 2023–24 league season, he was benched for the latter stages of the cup campaign for younger Brazilian Lucas Perri, including the 2–1 final loss to PSG.

[27] Lopes opted to represent Portugal, so his father made a phone call to the Portuguese Football Federation to alert to this fact,[28] and he first appeared with the under-21 side on 9 February 2011, playing the first 45 minutes of a 3–1 friendly win against Sweden in Cartaxo.

[30] On 31 March 2015, Lopes made his debut for the main squad, in a 0–2 friendly defeat to Cape Verde at the Estádio António Coimbra da Mota in Estoril.