Reyes attended the University of Southern California (USC), before the Cardinals selected him in the 15th round of the 2003 MLB draft, and made his major league debut on August 9, 2005.

During his playing career, Reyes threw and batted right-handed, stood 6 feet 2 inches (1.88 m) tall, and weighed 230 pounds (100 kg).

[6] On August 9, at Miller Park, Reyes made his major league debut, throwing 61⁄3 innings against the Milwaukee Brewers, earning the win and giving up just two runs on two hits.

[7] He was demoted immediately after the game, having fulfilled his role of giving the regular rotation an extra day's rest by manager Tony La Russa.

In the third game, Reyes threw 90 pitches, 67 for strikes, had six strikeouts and no walks, and carried a no-hitter into the seventh inning.

Reyes pitched an eight-inning complete game and took the loss despite giving up only the one hit (albeit a home run) to Thome.

[9] During the Cardinals' 2006 playoff run, Reyes was left off the roster for the National League Division Series against the San Diego Padres.

However, after advancing to the National League Championship Series against the New York Mets, the Cardinals added him to the roster in place of starting pitcher Jason Marquis.

[12] Reyes started Game 4 of the series and pitched four innings, allowing two earned runs on three hits and four walks, taking a no-decision in the 12–5 loss.

[16] He made three strong starts for the Redbirds and was recalled to St. Louis June 16,[17] but was optioned back to Memphis again on July 2.

[23] On September 6, Reyes exited his start after three innings against the Kansas City Royals due to a sore right elbow.

[29] During spring training his contract was purchased by the Indians, at which time he was placed on the 60-day disabled list, while recovering from Tommy John surgery.

[30] After spending the entire 2010 season on the disabled list, Reyes was outrighted to the Triple-A Columbus Clippers on October 29, 2010.

[33] Reyes became a Los Angeles County firefighter in March 2017, and was pressed into action to combat the wildfires in California later that year.