Apuron was ordained a priest on August 26, 1972, at Dulce Nombre de Maria Cathedral Basilica in Hagåtña, Guam by Archbishop Felixberto Flores.

[6] Claros announced that there would be no investigation into the allegations because "the policy of the archdiocese on sexual abuse calls for the victim to make a complaint", not a third party.

In 2014, Deacon Stephen Martinez told Apuron that he was violating the church's policy on the investigation of sex abuse accusations.

In a press release, the archdiocese said that Martinez's statements were "calumny of such magnitude that the only avenue, which we are following, is recourse to the civil and canonical legal processes to address these intentional lies".

Pereda, a clinical social worker and licensed therapist for over 30 years, said he had spoken with Quintanilla, a close relative, and would be willing to vouch for his credibility in court.

[13] On June 5, 2016, Pope Francis placed Apuron on leave to deal with the sexual abuse allegations and appointed as apostolic administrator Archbishop Savio Hon Tai-Fai to run the archdiocese.

CCOG said its purpose was to give members of the laity a voice in the operation of the archdiocese[15] On June 7, 2016, Walter G. Denton, another former altar boy from Agat, said that Apuron had sexually abused him in April 1977 when he was age 13.

Denton then sent a notarized letter describing his experiences to Archbishop Martin Krebs, apostolic delegate to the Pacific Islands, in August 2015.

In October 2016, the Congregation for the Doctrine of the Faith (CDF) in Rome assigned Cardinal Raymond Burke to preside over Apuron's trial on sex abuse charges in Guam.

[18] On October 31, 2016, Pope Francis replaced his apostolic administrator, Savio Hon Tai-Fai, with Archbishop Coadjutor Michael J.

Byrnes was given full authority over the archdiocese, but Apuron retained his title as archbishop pending the outcome of further appeals.

Byrnes stated later that year that Apuron did not leave him any records of the sex abuse allegations, counter to Church law.

[1] On March 23, 2021, US Federal District Judge Frances Tydingco-Gatewood denied Apuron's motion to temporarily halt proceedings in Guam's clergy sex abuse cases.

[29] In August 2021, court filings which were made public revealed that Apuron had testified in court to deny a former Father Duenas Memorial School student's allegations that Apuron raped and sexually abused him multiple times in the school year 1994–1995 at the then-archbishop's private residence in Agana Heights.