Santander was born on Margarita Island, off the Venezuelan coast, but grew up in and feels more connected to the mainland municipality Agua Blanca, where he returns every winter.

Seated in the left field lower deck right behind him, the scouts boisterously cheered for him whenever he caught a fly ball for almost the entire game after he had thrown a baseball as a souvenir to them early in the contest, and also because they recognised the European bank Santander.

[10] The Orioles responded to the exuberance by displaying a message on the center field video board referring to the scouts as the "Official International Anthony Santander Fan Club.

"[11] He matched teammate Renato Núñez's achievement from eleven days prior with his own first-ever five-hit game in an 8–3 home win over the Tampa Bay Rays three weeks later on August 25.

He tied an MLB record set by Ken Caminiti in 1996 by hitting home runs from both sides of the plate in a game for the fourth time in a single season in a 13–9 loss to the Boston Red Sox at Fenway Park on September 27, 2022.

His seventh-inning slam off Joe Jiménez while batting left-handed was his second home run of the match, both from opposite sides of the plate.

[22] He equaled his career-high five RBI in a pair of Orioles away victories that season over the Cincinnati Reds and Texas Rangers on May 5 and July 19 respectively.

[25] He surpassed Ken Singleton's 1979 franchise record for most homers by a switch-hitter in a season with his 36th off Jake Irvin in a 9–3 home loss to the Washington Nationals six days later on August 13.