The school is named for General Anthony Wayne, who led troops in the nearby Battle of Fallen Timbers during the Northwest Indian War.

The athletic teams of Anthony Wayne High School are known as the Generals and wear uniform colors of royal blue and white.

The Generals have 19 varsity sports that compete in the Northern Lakes League (NLL) in northwest Ohio, with the exception of the varsity ice hockey team, which competes in the Northwest Hockey Conference.

They compete in the Ohio High School Athletic Association (OHSAA), mostly in Division I. AWHS supports cross country, football, golf, soccer, tennis, girls' volleyball, basketball, bowling, boys' hockey, swimming, boys' wrestling, baseball, softball, lacrosse, dance team and track.

Anthony Wayne also features several club sports including crew, skiing and cheerleading.