BBC Radio 1 DJ Zane Lowe made "Anti-D" his "Hottest Record in the World" on 21 February 2011.

To celebrate Record Store Day, an exclusive "Anti-D" single, with different album art, was released.

The song, written by frontman Matthew Murphy, tells the story of his addiction to anti-depressants, which he had been taking to combat his anxiety and which he said made him "a mess".

He claims that the main reason he felt he had to come off the pills was the fact that he was gaining weight, which inspires the line, "Then there's the extra two stone that's our only guarantee."

John Fernandez of music blog There Goes the Fear gave the song a positive review, saying, "It's by far their most grown-up single so far; the lyrics are hard hitting, and while I myself may not be able to relate to it easily, I can imagine that it strikes a chord with the audience they are looking for.