Gaining popularity through the punk underground, Anti-Flag controversially signed to RCA Records and released their major label debut For Blood and Empire in 2006.

It contained singles such as "The Press Corpse" (which was the band's only appearance on the US Alternative Airplay chart) and "This is the End (For You My Friend)", which featured in multiple video games.

The band remained active past their commercial peak, releasing a total of thirteen albums, the last of which came out months before their disbandment.

Anti-Flag suddenly broke up in July 2023 amidst several rape and sexual assault allegations made against Sane.

In March 2024, Sarhadi's legal team learned that Sane had sold his Pittsburgh home and transferred funds to a bank account in Ireland, where he holds dual citizenship.

After Andy's departure in 1996, Sean Whelan from the Pittsburgh band the Bad Genes briefly filled in as their bassist.

In 2001, Anti-Flag teamed up with punk music producer Mass Giorgini to record the album Underground Network on Fat Wreck Chords.

The album addressed the topics of fascism (specifically neo-Nazis infiltrating the "hardcore scene") and the foreign policy of the United States.

The album was the first of theirs to contain the now-commonplace booklet filled with essays from historians and political commentators, most notably Professor Howard Zinn.

In the wake of the September 11 terrorist attacks on the United States, Anti-Flag spoke out against the push for war with the album's title track, "911 for Peace".

These bands include The Code, Pipedown, Much the Same, The Vacancy, The Unseen, Modey Lemon, Thought Riot, Tabula Rasa, and many others.

2 joined Billy Talent singer Ben Kowalewicz and guitarist Ian D'Sa, singing their new song "Turn Your Back" from their upcoming unreleased album.

In March 2009, Anti-Flag was forced to cancel a series of tours after Sane broke his collarbone at the UEA LCR in Norwich by jumping off the stage, trying to stop someone that was throwing objects at the band.

The first track of the album "Sodom, Gomorrah, and Washington DC (Sheep in Shepherd's Clothing)" could be listened to on Anti-Flag's website.

In March–April 2011, Anti-flag made a live comeback by headlining a South American tour with This Is a Standoff, and supporting My Chemical Romance in the U.S.

[9] On March 20, 2012, Anti-Flag released an album called The General Strike, which was recorded and produced by the band at their home studio.

On January 16, 2015, Anti-Flag announced they would release their ninth studio album called American Spring on the label Spinefarm Records.

[14] On August 14, 2017, in reaction to the events of the 2017 Unite the Right rally, the band released a song titled "Racists" to the Spinefarm Records YouTube channel.

[19] On the band's website, the song's meaning was explained by a quote from Justin: History is full of wealthy and powerful people using religion and cultism to justify policies of oppression and inequality.

Theocracy is dangerous and inherently anti-democratic because it restricts individual choice and provides an avenue by which politicians can claim a moral superiority over "the other".

The band took a different approach than usual during recording by not only writing a concept album, but bringing in guest musicians for multiple tracks.

[26] The band officially announced their final album Lies They Tell Our Children on July 29, 2022, alongside the release of the single "Laugh.

A music video was also released for the song, which depicts an individual spray painting the walls of an abandoned school with various messages that the band deemed as lies.

Meanwhile, Thetic, Head, and Barker released a statement expressing their shock and sadness upon hearing the allegations, starting with, "A core tenet of the band Anti-Flag is to listen to and believe all survivors of sexual violence and abuse.

"[36] Following an exposé published by Rolling Stone in September – revealing twelve additional women and girls who accused Sane of sexual misconduct, "serious sexual assaults", grooming and rape – Thetic, Head, and Barker released a second statement directly condemning Sane, stating they believed he was "in need of serious professional help" and that "it appears you used our beliefs as a cover for egregious activities that you clearly knew we would never condone.

"[37][38] In November 2023, the original accuser from the July podcast episode sued Sane for sexual assault under the New York Adult Survivors Act.

[39][40] In an amendment to her initial complaint in March 2024, the accuser questioned the rest of the band members' insistence that they were unaware of Sane's actions, accusing Thetic, Head, and Barker of being "aware of [Sane]'s practice of sexually assaulting young women and girls," and claiming that the band's self-owned distribution company, Hardwork Distribution, "aided and abetted such behavior."

[38][40][41] In March 2024, the accuser's legal team stated that they believed Sane had approximately 60 victims and that one witness who came forward and had their testimony included in the accuser's lawsuit claimed that at a 2002 album release party in Pittsburgh, they witnessed "the members of Anti-Flag [mingling] outside the venue with clearly underage girls" who appeared "to be between 14 and 15 years old," and that Sane and other band members were "hugging and inappropriately kissing them.

[44] In September 2023, members of Anti-Flag informed that they were "in the process of unwinding the label, including returning master rights and physical records/merchandise to the bands," although they stated this would "take some time to complete properly.

Anti-Flag's song "Die for Your Government" was sung by anti-war protesters who briefly barricaded a road to prevent U.S. troops from deploying to Iraq in August 2010.