[5] AMHR2 belongs to TGF-β type II receptor family and adopts the characteristic three-finger toxin fold.

However, it displays a unique extended finger 1 loop (see image) that is critical to effectively binding its ligand, AMH.

The palm region and other fingers are also implicated in binding to AMH, but are relatively unremarkable when compared to other TGF-β type II receptors.

[13] PMDS can be caused by a genetic mutation of deletions, or missenses, and these males often have undescended testes or cryptorchidism, where one testis fails to descend outside of the body cavity.

However, heterozygous females have been observed to reach menopause sooner and display a lowered AMH level which also is an indicator of antral follicle count.