Humoral immune deficiencies are conditions which cause impairment of humoral immunity, which can lead to immunodeficiency.

It can be mediated by insufficient number or function of B cells, the plasma cells they differentiate into, or the antibody secreted by the plasma cells.

[7] The most common such immunodeficiency is inherited selective IgA deficiency, occurring between 1 in 100 and 1 in 1000 persons, depending on population.

They are associated with increased vulnerability to infection, but can be difficult to detect (or asymptomatic) in the absence of infection.

[citation needed] Signs/symptoms of humoral immune deficiency depend on the cause, but generally include signs of infection such as:[1] Cause of this deficiency is divided into primary and secondary: In terms of diagnosis of humoral immune deficiency depends upon the following:[5][6] Treatment for B cell deficiency (humoral immune deficiency) depends on the cause, however generally the following applies:[5] peripheral: Purine nucleoside phosphorylase deficiency