Antidepressant is the seventh solo studio album by English musician Lloyd Cole, released on 25 September 2006 through Sanctuary Records.

It contains a cover of American rock band Moby Grape's "I Am Not Willing" and contributions from Jill Sobule as well as Cole's former Commotions bandmate Neil Clark.

[2] Thom Jurek of AllMusic described the album as "an interesting mirror image to 2003's dark and moody Music in a Foreign Language.

These songs are about mid-life, its traps, compromises, disappointments, and the hidden delights found in aging".

"[2] Preston Jones of Slant Magazine called Antidepressant "40 minutes of positively luminous pop" in which Cole paints his "anxious desperation as a series of low-key melodies", summarising it as a "prescription for sweetly downcast pop that will cure whatever ails you".