The club was founded in 1958 by Dr. Miguel Ángel Soto Bustamante and Mr. Antonio Martínez Barrios with the colonial city as its home.

After earning promotion to the maximum division (Liga Mayor "A") in the 1957–58 season,[1] Antigua finished third in the 1959–60 league table.

[4][6] Administration changed hands again and the team earned another promotion in 1979 after winning a tie-breaking third playoff match against Juca at the Estadio Mateo Flores, remaining in the top category until 1983, when a last-place finish on the standings relegated them once again.

[7] Relegation in 1983 marked the beginning of a 16-year-long period in which the club went through financial strain and was unable to return to the top flight.

Antigua compete in Guatemala's highest-level league having purchased the position offered by the Heredia Jaguares from Izabal.