Relations between Antigua and Barbuda and the Republic of Colombia began on 18 March 1982, less than a year after the former's independence from the United Kingdom.

[1] The bilateral programmes of these two countries is governed mainly by the Programs of the Colombian Cooperation Strategy in the Greater Caribbean.

[1] The programme is aimed at inhabitants of the Caribbean islands who want to strengthen specific issues.

[2] With Antigua and Barbuda, cooperation has occurred through topics such as:[3] In 1994, CARICOM and Colombia signed a free trade agreement aimed at promoting trade and investment, cooperation and the creation of joint ventures.

The products exported from Colombia to Antigua and Barbuda included Cement ($1.47M), Raw Sugar ($202k), and Petroleum Coke ($173k).