Antigua & Barbuda was represented at the 2006 Commonwealth Games in Melbourne by a contingent comprising 18 sportspersons.

Even though the nation did not earn a medal at these Games, the 4 x 100 relay team, featuring N'Kosie Barnes, Ivan Miller, Daniel Bailey, and anchor Brendan Christian, broke the Antigua & Barbuda national 4 x 100 record in the heats with a time of 39.9 seconds, and placed fifth in the finals.

The following is the list of number of competitors participating in the Games.