Antimachus II Nikephoros (Greek: Ἀντίμαχος Β΄ ὁ Νικηφόρος; the epithet means "the Victorious") was an Indo-Greek king.

In both of Boperachchi's reconstructions, Antimachus II was succeeded by Menander I who inherited three of his four monograms.

Antimachus II probably fought against the Greco-Bactrian king Eucratides I, who had dethroned his father in Bactria.

Antimachus II did not strike a portrait on his coins, likely since this was not custom in India.

Antimachus II struck a large number of bilingual drachms on the same lighter Indian standard as Apollodotus I, though round in shape.